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2025 Week 4 NFL Fantasy Injury Preview

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2025 Week 4 NFL Fantasy Injury Preview

Follow Dr. Edwin Porras on his fantasy football account here and see what his day job is in the Denver area

Jayden Daniels - Knee

Almost 100% of the time when a QB practices leading up to a game, he plays. But with the way the Commanders med staff is operating this year they’re playing it extremely safe. Given the fact that he’s been practicing and looking good this week, it would be legitimately shocking to see him miss Week 5.

Projected Return: Week 5

Terry McLaurin - Quad

McLaurin left with a quad strain. Typically, these injuries don’t take long to recover from. Until we hear more, we tentatively expect McLaurin to play in the short term. Adam Schefter called him “uncertain” for Week 4.

Projected Return: Week 5-7

Update: Quad injuries don’t typically take as much time as other soft tissue injuries which is why I was optimistic. Clearly this is a bigger issue than we thought. If McLaurin can practice without setbacks next week, Week 5 is in the cards.

Chris Godwin - Ankle fracture

These injuries take a long time to truly recover from. Historical data shows WRs can bounce back but it likely won’t be a massive performance for Godwin this week.

Projected Return: Week 4

CeeDee Lamb - High Ankle

The average amount of missed time with injuries this severe is 2.4 games. The median is 2 games. Specifically for WRs who tried to return at 2 weeks or before, 25% of them reinjured. Lamb might try to give it a go earlier than that, but it’s not likely he can do it without a severe reinjury risk.

Projected Return: Week 6-7

Mike Evans: Hamstring

We’ve done this dance with Evans before.

Hamstring strains, also known as “soft tissue” injuries, can be particularly challenging for players due to their high 30% reinjury rate. Evans, in particular, is in his 30s and has been dealing with this issue for years so even if he plays, he’s at severe reinjury risk.

After these injuries, WRs have an 18% Week Winner rate. In other words? High-risk, high-reward.

Projected Return: Week 6-8

Xavier Worthy - Shoulder

Worthy doesn’t carry a designation heading into this week. His WR skills shouldn’t be diminished but he’s highly volatile. One hit to the shoulder and he’s out with surgery on the table.

Colston Loveland - Hip

Loveland landed on his hip hard — definitely painful, but Schefter reports it’s not serious. He’s likely to play as long as he practices this week.

Projected Return: Week 4

Tyrone Tracy - Shoulder Dislocation

Projected Return: Week 6-8

Michael Mayer - Concussion

Projected Return: TBD

Projected Returns

J.J. McCarthy - High Ankle

Projected Return: Week 6-7

Brandon Aiyuk - ACL

Projected Return: Week 5

Joe Burrow - Toe

Projected Return: 2026

Xavier Worthy - Shoulder

Projected Return: Week 4

Brock Purdy - Toe

Projected Return: Week 4

Jayden Daniels - Knee

Projected Return: Week 5

James Conner - Ankle

Projected Return: 2026

Najee Harris - Achilles

Projected Return: 2026

Edwin completed his Doctorate of Physical Therapy education in 2020. His expertise is in all thing’s orthopedics, injury recovery, and he has a special interest in human performance. Edwin’s vision is to push injury advice past simple video analysis and into the realm of applying data from the medical literature to help fantasy players make informed start-sit decisions.